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3D LC-OCT Skin Biomarkers for Evaluating Skin Hydration and Barrier Function
Short talk
Session 3: Hydration evaluation, what's new?
Day 2
10:00 am
LC-OCT (Line-field Confocal Optical Coherence Tomography) enables non-invasive, real-time 3D imaging of the skin at cellular resolution. This cutting-edge technology provides detailed visualization of key skin structures, including the stratum corneum, epidermis, dermo-epidermal junction, dermal fibers, keratinocyte nuclei, and melanin. By capturing high-resolution images, LC-OCT offers unique insights into skin biology and mechanisms.
In the context of dermo-cosmetic research, LC-OCT enables precise evaluation of the effects of topical formulations on skin hydration and barrier integrity. When combined with advanced AI algorithms, it provides robust, quantitative, and reproducible metrics of skin microarchitecture and composition in vivo over time. These parameters serve as objective and reliable endpoints for product development and clinical studies, making LC-OCT a powerful tool for understanding skin physiology and evaluating the efficacy of hydration-focused cosmetic treatments
Margot Vasseur
Damae Medical
Margot is an Application Engineer at DAMAE Medical and has been actively involved in the development of the dermo-cosmetic division for the past two years. With a background in biotechnology engineering, she has developed strong expertise in LC-OCT image interpretation and in the extraction and analysis of quantitative skin biomarkers. Her work focuses on translating high-resolution 3D imaging data into meaningful insights to assess skin structure, function, and product efficacy for cosmetic and pharmaceutical research.
Damae Medical develops an in vivo imaging device and AI solutions for advanced 3D visualization and quantification of the skin at the microscopic scale, supporting dermo-cosmetic and pharmaceutical research. Since 2014, its deepLive™ technology integrates LC-OCT (Line-field Confocal Optical Coherence Tomography), which combines the principles of OCT (Optical Coherence Tomography) and RCM (Reflectance Confocal Microscopy). This innovation enables a true non-invasive optical biopsy of the skin: real-time 3D imaging that reveals cutaneous structures with cellular precision — including the stratum corneum, epidermis, dermo-epidermal junction, dermal fibers, keratinocyte nuclei, and melanin.
Combined with advanced AI algorithms, deepLive™ provides microscopic-scale quantification of the skin, enabling accurate characterization and reliable evaluation of product efficacy. Certified CE Class IIa, FDA-approved, and deployed in more than 14 countries, deepLive™ is trusted by leading cosmetic and pharmaceutical companies worldwide.
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