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Dermal Interstitial Fluid: Pain- Free Sampling of Molecular Biomarkers in
Clinical Studies
Short talk
Session 1: Hormones influence on Skin & Hair
Day 1
0:30 pm
Dermal interstitial fluid (dISF) is a highly-concentrated biofluid that surrounds cells in skin tissue. dISF is highly concentrated in molecular biomarkers and therefore comprises a novel alternative for biomarker analysis to blood or skin biopsy, enabling higher patient comfort and continuous biomarker monitoring. Ascilion has developed a system utilizing hollow microneedles and gentle subpressure application, capable of sampling dISF in a pain-free manner. Importantly, the volumes of dISF sampled are useful for high-sensitivity molecular assays and biomarkers panels. Interestingly, biomarker species quantifiable in dISF include dermal inflammation markers, skin barrier and health markers, hormones, lipids, and both endogenous and exogenous (bacterial) metabolites.

Jeremy Bost

Ascilion
Jeremy Bost, Ph.D. is the Head of Clinical Affairs at Ascilion, an emerging medical device company based in Stockholm Sweden. Ascilion currently has customers using the miconeedle-based PELSA system in 12 countries on 5 continents, and has been involved in over 20 clinical studies to date. Dr. Bost has worked in translational and clinical research with a focus in dermatology and medical devices.
Ascilion is a medical device company pioneering minimally invasive access to dermal interstitial fluid (dISF) to unlock a new generation of biomarker-driven diagnostics and monitoring. The company has developed a proprietary microneedle-based system designed to collect dISF in a simple, patient-friendly, and reproducible way, without the pain or complexity of traditional blood draws or skin biopsies. Because dISF reflects dynamic physiological processes at the tissue level, it offers rich insights into cosmetic efficacy, therapeutic response, and health status across a range of skin types. Ascilion’s platform is built to integrate seamlessly into clinical and research workflows, enabling high-quality sample collection suitable for advanced analytical methods. By making dISF accessible at scale, Ascilion aims to accelerate biomarker discovery, support precision medicine, and empower clinicians, researchers, and industry partners with more actionable biological data—bringing diagnostics closer to the biology that matters most.
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