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The Gut-Skin-Brain Axis: A Psychophysiological Approach in Cosmetic
Conference
Session 4: Skin & Brain Axis
Day 2
3:20 pm
The complexity of the interconnections of the gut-skin-brain axis has emerged as a major field of research. This cross-communication is regulated by neuronal, endocrine, and immune pathways.
In this presentation, we will explore the hypothesis that disruptions linked to psychosocial stress and dysbiosis directly affect skin homeostasis. We will illustrate how these systemic dysregulations manifest at the
cutaneous level, leading to impaired barrier function and increased sensitivity to inflammatory markers.
We will detail some possible non-invasive in vivo assessment methodologies with a psychophysiological approach.
In conclusion, our talk will highlight the potential of cosmetic products to act as peripheral modulators of the gut-skin-brain axis, opening the way to a paradigm shift towards holistic and systemic cosmetics, beyond traditional anti-aging.

Edith Filaire

ICARE
Edith Filaire is a French researcher whose career spans several major universities, including Lyon 1, Clermont-Ferrand, and Orléans-Paris Saclay. Professor and co-director of a research laboratory, she has conducted research on the psychophysiological links between nutrition and health. After spending four years defining the scientific strategy of the GREENTECH GROUP in the fields of skin biology, neuroendocrinology, and microbiota, she now holds the position of Director of Research and Innovation at the ICARE GROUP. She works on alternative methods to animal testing in the field of medical devices and pharmaceuticals by developing skin-on-chip models to assess skin sensitization. She is the author of more than 150 scientific articles and eight book chapters.
The Icare Group has a high level of scientific expertise in cellular and animal biology. The group offers in vivo and in vitro toxicology and mutagenesis services to the chemical, phytosanitary, and pharmaceutical industries, in accordance with current OECD standards. The Group also evaluates the biocompatibility of medical devices according to ISO 10993 standards. Recognized by international authorities, particularly in Europe and Asia, the Group is committed to collaborating with manufacturers in the chemical, agrochemical, and pharmaceutical industries to demonstrate the safety of their products. The ICARE Group's tests enable chemical and pharmaceutical products to be authorized for marketing in accordance with international regulations (e.g., REACH). The group specializes in testing the safety and efficacy of implantable devices, medicines, and chemical products.
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