Clément Milet
Laboratory Director
CTI Biotech
Biography
Clément Milet joined CTIBIOTECH in 2017 to lead the 3D bioprinting program, strengthening its capabilities in advanced 3D cell and tissue culture. With a background in cancer research technologies, including RNA screening and translational oncology, he developed strong expertise in three-dimensional tumor models. At CTIBIOTECH, he applied this knowledge to patient-derived cancer and skin tissues, creating 3D-bioprinted microtumor and skin models. He also contributed to advanced skin models for cosmetic testing and safety assessment. Since 2020, he has served as Laboratory and Quality Director, overseeing research programs and expanding production capacity through industrial-scale 3D bioprinting.
Conference
Day 2
Session 4: Skin & Brain Axis
Does your perfume or cosmetic feel good? Now you can tell with computer-connected artificial neural-skin to evaluate cosmetics in real-time testing
How we feel as we are constantly bombarded from the outside can be changed when we use cosmetics or perfumes. But everyone has different sensations. On top of that, how a cosmetic or fragrance can feel or smell depends on what your skin has already been exposed to. The short-term exposome and long-term exposome are both important to evaluate to really understand how humans from diverse backgrounds, working outside or primarily inside will react to their cosmetic product. By combining IPS-derived neural cells or neural cell lines into a 3D epidermis-dermis model it is possible to not only have short-term readout through electrical variation, but also follow over time the intercellular molecular communication and biomechanical effects of cosmetic applications. We are developing cosmetic tests for sensation for different complexities and costs to be able to better help new cosmetic innovations as well as the longer existing brands. By using cell lines, as well as primary human tissues, neural cells were able to penetrate throughout the skin model created with 3D bioprinting and maturation of the neural cells in vitro. Although electrical activity can be measured, the structure of the skin and intra- and inter- cellular communication is also key in evaluation of response.